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Country: Israel
City: Tel Hashomer
IHTC:
National Hemophilia Center
Sheba Medical University
Tel Hashomer 52621, Israel
Tel.: 972 3535 7357; 972 3530 2409
Fax: 972 3535 1806
Email: martinur@beziqint.net
Director: Uri Martinowitz
Responsible for training: Uri Martinowitz, Gili Kenet
Fellowship logistics coordinator:
Year of IHTC designation: 1993
Areas of specialty: General hemophilia care; orthopedic surgery; nursing; physiotherapy; dental; laboratory diagnosis (not genetics); psychology; social work.
DESCRIPTION OF TRAINING PROGRAM
Clinical activities: The Israeli Natoinal Hemophilia Center (INHC) is located at the Sheba Medical Center. The hospital is the largest referral centre in the country, which serves a population of over one million. There is a comprehensive institute of thrombosis and hemostasis in addition to the hemophilia centre.
Unique services include: Pediatric Coagulation Service for diagnosis, consultation and treatment of children with hemophilia and other bleeding disorders. This service is a unique tertiary referral for consultation, evaluation and treatmnet of pediatric patients who eperiences ischemic stroke, arteial or venous thrombosis, and provides anticoagulant treatment and long-term follow-up for children. Prenatal diagnosis and carrier detection of hemophilia A and B assisted by the laboratories of the Institute of Thrombosis and Hemostasis. Consulting Service for physicians in Israel and worldwide, providing solutions for bleeding hemophilia patients or any uncontrolled bleeding in patients with inherited or acquired coagulopathies, as well as trauma cases.
Special techniques developed by the centre (and adopted worldwide) include: Administration of factor replacement concentrates by continuous infusion; development and use of special antifibrinolytic fibrin-sealants; treatment of life-threatening bleeding in trauma patients / surgical patients without pre-existing coagulopathy by recombinant activated factor VII.
Research programs include: Development of new versions of fibrin glue, design and performance of clinical trials on fibrin glue in patients with and without bleeding disorders undergoing various surgeries; the effects of physical fitness / activity on bleeding profile of hemophilia patients; applicatoin of continuous infusion for practical treatmnt in hemophilia; development of new method for screening of bleeding disorders and for monitoring replacement therapy; evaluation of new concentrates - stability, bacterial resistance, suitability for continuous infusion, pharmacokinetic evaluation; participation in internatoinal multi-centre studies (i.e. PUPs studies, etc.)
Laboratory activities/research: The coagulation laboratory includes both routine and research labs in which si PhDs and si technicians and students work. Routine activities include screening for all bleeding disorders, as well as thrombotic disorders, DNA analysis for hemophilia, vWD, platelet abnormalities and thrombophilic states.
Multidisciplinary activities/research: All together, there are 3 nurses, 10 physicians, including adulat and pediatric hematologists (6), an infectious disease specialist, a liver specialist, and orthopedic surgeouns who are dedicated to patients with bleeding as well as with thrombotic disorders. HIV and hepatitis-related conditions are treated at the INHC as well. Additional services are offered by a social worker, psychologist, physical therapis and genetic counsellor. A comprehensive dental service located at a neighbouring building collaborates closely with our center.
Additional information: The INHC serves the entire hemophilia populatoin of the country (over 400) and supervises activities in other centres. All surgical procedures and operations in hemophilia patients are referred to the INHC from the entire country.
DESCRIPTION OF IHTC FACILITIES
Location: The INHC is a modern building located at the Sheba Medical Center near Tel-Aviv (15 min. driving distance) and Jerusalem (45 min. driving distance) on the Tel Hashomer campus. There is also the Israeli Central Blood Bank as well as a comprehensive rehabilitation centre.
Climate:
Accommodation (residence, meals, etc...): There are rooms and cottages available for rental in the campus area.
Transportation: Buses/taxis to Tel-Aviv operate 24 hours a day.
Language: English
Financial assistance: Dependent on WFH funds.
Cost of living (per week):
Communications tools for trainees:
Other local support provided for trainees:
RELEVANT PUBLICATIONS BY IHTC STAFF
Varon, D., Martinowitz, U. Continuous infusion therapy in haemophilia. Haemophilia 4, 1998 431-436.
Martinowitz, U., Varon, D., Heim, M., The role of fibrin tissue in surgery of haemophilia patient. Haemophilia 4, 1998 443-449.
Martinowitz, U., Kenet, G., Segall, E., Luboshitz, J., Lubetsky, A., Ingerslev, J., Lynn, M.: Recombinant activated factor VII for adjunct hemorrhage control in trauma. Journal of Trauma 51; 3: 431-8, 2001.
Kenet, G., Sadetzky, S., Murad, H., Martinowitz, U., Rosenberg, N., Gitel, S., Rechavi, G., Inbal, A.: Factor V 1 Leiden and antiphospholipied antibodies are significant risk factors for ischemic stroke in childre. Stroke 31, 6: 1283-8, 2000.
Kenet, G., Lubetsky, A., Luboshitz, J., Martinowitz, U.: A New Approach to Treatment of Bleeding episodes in young Hemophilia patients: a single bolus mega-dose of Recombinant Activated Factor VII (NovoSeven) Journal of Thrombosis and Haemostasis, 2003. |
