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Country: Italy
City: Milan
IHTC:
Angelo Bianchi Bonomi Hemophilia and Thrombosis Centre
IRCCS Maggiore Hospital
Via Pace, 9-20122
Milan, Italy
Tel.: 39 02 5503 5421; 39 02 5503 5414
Fax: 39 02 5410 0125
Email: piermannuccio.mannucci@unimi.it;
flora.peyvandi@unimi.it
Director: Pier Mannuccio Mannucci
Responsible for training: Flora Peyvandi (genetic lab and rare diseases), Elena Santagostino and Alessandro Gringeri (hemophilia), Augusto Federici (von Willebrand disease) and Rossella Bader (coagulation lab)
Fellowship logistics coordinator: Patricia Milani
Year of IHTC designation: 1972
Areas of specialty: General hemophilia care; laboratory diagnosis (not genetics); genetic diagnosis.
DESCRIPTION OF TRAINING PROGRAM
Clinical activities: The hemophilia centre is attached to a division of internal medicine and has, at the moment, 3 staff physicians for clinical duties and clinical research. Over the 30 years of activity of the centre, at least one-third of the Italian patients with bleeding disorders have been seen and treated. We follow at least 500 patients with severe bleeding disorders, severe enough to require regular medical attention, are diagnosed at the centre. We regularly follow 120 patients with HIV infection, some of whom come from other regions, because we provide and supervise directly anti-retroviral tretment and treatment of opportunistic infections. The main strength of the centre is the close link between clinical and research activities, and the application of relatively sophisticated laboratory techniques (protein chemistry, molecular biology) to clinical research.
Laboratory activities/research: The main strength of the centre is the application of relatively sophisticated laboratory techniques (protein chemistry, molecular biology) to clinical research.
Multidisciplinary activities/research: We provide in- and out-patient management, and we regularly enlist the help of orthopedic surgeons and dentists with a special interest in hemophilia care.
Additional information: Every year, the centre trains at least 3-4 physicians or technicians from developed and developing countries, and our staff has acquired considerable skill in this endeavour. The centre has enjoyed the status of IHTC since 1972. We are also a Thrombosis Vascular Training Centre of the International Society for Thrombosis and Haemostasis, so trainees can also be exposed to a thrombosis program.
DESCRIPTION OF IHTC FACILITIES
Location: The hemophilia centre is located in the centre of Milan, at the largest academic hospital in the city.
Climate: Continental climate. The best seasons are spring and autumn.
Accommodation (residence, meals, etc...): At the moment, there are no special facilities for residence and meals, but trainees can share the same opportunities as the staff members around the hospital.
Transportation: Public transport available.
Language: Italian. Most staff members speak English, and some speak Spanish.
Financial assistance: We cannot provide supplementary financial assistance, unless the trainee is prepared to remain with us longer than 1-3 months to carry out a research project.
Cost of living (per week): 450 USD
Communications tools for trainees: Computer, Internet access.
RELEVANT PUBLICATIONS BY IHTC STAFF
Rumi, MG, Santagostino E, Morfini M, Gringeri A, Tagariello G, Chistolini A, Pontisso P, Tagger A, Colombo M, Mannucci PM and the Association of Italian Hemophilia Centres. A multicentre controlled, randomized, open trial of interferon alpha2b treatment of anti-human immunodeficiency virus-negative hemophilic patients with chronic hepatitis C. Blood 89: 3529-3533, 1997.
De Filippi F, Colombo M, Rumi MG, Tradati F, Prati D, Zanella A, Mannucci PM. High rates of hepatitis G virus infection in multitransfursed patients with hemophilia. Blood 90: 4634-37, 1997.
Tradati F, Colombo M, Mannucci PM, Rumi MG, De Fazio C, Gamba G, Ciavarella N, Rocino A, Morfini M, Scaraggi A, Taioli E and the Study Group of the Association of Italian Hemophilia Centres. A prospective multicentre study of hepatocellular carcinoma in Italian hemophiliacs with chronic hepatitis C. Blood 91: 1173-7, 1998.
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