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Country: United Kingdom
City: Sheffield
IHTC:
Sheffield Haemophilia and Thrombosis Centre
Royal Hallamshire Hospital
Glossop Road
Sheffield , S10 2JF
United Kingdom
Tel.: 44 114 271 3211 (centre); 44 114 271 2500 (secretary)
Fax: 44 114 275 6126
Email: m.makris@sheffield.ac.uk
Director: Mike Makris
Responsible for training: Mike Makris
Fellowship logistics coordinator:
Year of IHTC designation: 1992
Areas of specialty: General hemophilia care; laboratory diagnosis (not genetics); genetic diagnosis.
DESCRIPTION OF TRAINING PROGRAM
Clinical activities: The Sheffield Haemophilia and Thrombosis Centre is a comprehensive care hemophilia centre, located in Sheffield, U.K. It has approximately 800 pediatric and adult patients with all forms of inherited bleeding disorders. There is a dedicated hematology ward and the hemophilia service is staffed by three consultants in hemostasis and thrombosis (Drs. Mike Makris, Eddie Hampton, and Rhona Maclean). In addition, there are two hemophilia nursing sisters and one physiotherapist. There is also a bi-monthly combined hemophilia/orthopedic clinic.
Laboratory activities/research: There is a large coagulation laboratory, directed by Dr. Steve Kitchen, which undertakes all of the investigations necessary for the diagnosis and management of patients with inherited and acquired bleeding and thrombotic disorders. The laboratory regularly participates in the calibration of WHO International standards, which has included standards for factors II, VII, VIII:C, IX, X, vWF antigen and activity, PC, PS and AT. Staff from the centre are active in national and international bodies associated with hemostasis and thrombosis, including the WFH and the science and standardization committees of the International Society on Thrombosis and Hemostasis. In addition, there is a large Molecular Genetics Unit directed by Prof. Ian Peake and Dr. Anne Goodeve. Main areas of interest of the molecular genetics laboratory include hemophilia and von Willebrand disease.
Additional information: Sheffield Haemophilia and Thrombosis Centre is a World Health Organization (WHO) Collaborating Centre for the Diagnosis and Comprehensive Care of Patients with Bleeding and Clotting Disorders. In addition, the UK National External Quality Assessment Scheme (UK NEQAS) in Blood Coagulation and also the WFH-WHO International External Quality Assessment Scheme (IEQAS) operate from the Royal Hallamshire Hospital, Sheffield, under the directorship of Prof. Eric Preston.
DESCRIPTION OF IHTC FACILITIES
Location: Sheffield Haemophilia and Thrombosis Centre is situated in Sheffield, U.K. Sheffield covers a population of two million inhabitants. Sheffield is located in the centre of the United Kingdom, in close proximity to the Peak District National Park. It has all the student facilities and environment one would expect from a university city.
Climate: The climate is temperate, with possible snow in winter but mild in summer, sometimes with rain.
Accommodation (residence, meals, etc...): Hospital accommodation is available nearby at reasonable rates, with good cafeteria facilities within the hospital. The cost of living is less expensive than in major European and North American cities.
Language: English, Greek
Financial assistance: Dependent on WFH funds.
Cost of living (per week): 530 USD
Communications tools for trainees: Computer, Internet access.
RELEVANT PUBLICATIONS BY IHTC STAFF
Kitchen S, McCraw A (2001). Laboratory Manual for Diagnosis of Haemophilia and Other Bleeding Disorders: on behalf of World Federation of Hemophilia.
Goodeve, AC. Laboratory methods for the genetic diagnosis of bleeding disorders. Clinical and Laboratory Haematology 1998; 20:3-19.
akris M. et al. Guidelines on the diagnosis, management and prevention of hepatitis in hemophilia. Haemophilia 2001; 7: 339-345.
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