Types of prophylaxis
Unlike episodic or “on demand” treatment, which is given at the time of a bleed to make it stop, prophylaxis is given to prevent bleeding before it starts.
There are several types of prophylaxis. Continuous prophylaxis (primary, secondary, and tertiary) is given regularly over a period of several months and often years. Intermittent or periodic prophylaxis is given for shorter periods of time, usually a few weeks or months.
|Type of Treatment||Definition|
|Episodic (“on demand”) treatment
||Treatment given at the time of bleeding.
|Regular continuous treatment, started before the second large joint bleed and age of 3 years.
||Regular continuous treatment started after 2 or more large joint bleeds but before the onset of joint disease.
||Regular continuous treatment started after the onset of joint disease to prevent further damage.
|Intermittent (“periodic”) prophylaxis
||Treatment given to prevent bleeding for short periods of time, such as during and after surgery.
Adapted from: Guidelines for the Management of Hemophilia, World Federation of Hemophilia, 2012.
Note: These definitions are consistent with those published by the Factor VIII & IX Scientific Standardization Committee of the International Society on Thrombosis and Haemostasis. National or regional programs may rely on other definitions.
Updated December 2014