Country: Brazil
City: Campinas, SP

Hemocentro – “Unidade de Hemofilia Cláudio Luiz Pizzigatti Corrêa” – Hemocentro Unicamp, University of Campinas
Rua Carlos Chagas 480 – Cidade Universitária Zeferino Vaz
PO Box 6198
Campinas, SP, Brazil – 13.081-878
Tel.: 55-19-35218395, 55-19-35218256
Fax: 55-19-53218760

Margareth Castro Ozelo, M.D., Ph.D.
Medical Associates: Dr. Margareth Castro Ozelo, Dr. Samuel de Souza Medina, Dr. Carolina Silva Costa, Dr. Rodrigo Pagnano
Fellowship logistics coordinator: Nunziela Biondi
Year of IHTC designation: 2008

Areas of specialty: Adult and pediatric hematology; Laboratory diagnosis and molecular genetics; Nursing; Dentistry; Physiotherapy;


Location: Campinas has a population of approximately 1 million inhabitants and is situated 97 km from Sao Paulo (southeast area). It has played a strategic role in the development of its region by industry, services and technology generation. 

Climate: Campinas has an excellent climate characterized by mostly sunny and hot days. The average temperature is 22.3° C and the rainy season is from November to March.

Accommodations: Close to our center, inside the campus of the university there is a hotel with reasonable rates. Private and shared residences are also available in the neighbourhood.

Languages: English, Spanish, and Portuguese


Clinical activities: The Hemophilia Treatment Unit (HTU) is part of the Hematology and Hemotherapy Center of State University of Campinas (Hemocentro UNICAMP), an institution that provides general hematological care and blood banking services. Our centre has 708 patients with diagnosis of inherited bleeding disorders. To provide assistance for these patients we have a multi-disciplinary team of 16 professionals who have dedicate their career to hemophilia care.

The objective of our Comprehensive Care Training Program is to offer to the trainees an opportunity to learn by experience the most important aspects of the comprehensive care of patients with hemophilia in an HTU with in and out-patient facilities, a laboratory with capability to perform functional and molecular tests of hemostasis, a multi-disciplinary team devoted to the care of patients with hemophilia and different treatment programs such as secondary and short-term prophylaxis, on-demand and home treatment, radiosynoviorthesis, immune tolerance induction, physiotherapy, psycho-pedagogical support as well as research in the field of hemophilia.

Laboratory activities/research: There are purpose-built designated laboratories which manage the tests required for the treatment of hemophilia, the diagnosis of new bleeding disorders and the molecular basis of bleeding disorders with provision for ante-natal diagnosis. The laboratory also provides a routine haemostasis service for the Royal Free Hospital.

Laboratory result meetings are held regularly to discuss the ongoing work up of the complex cases that are sent to this tertiary referral centre. Several research areas are always active. Currently gene therapy, global hemostasis assays, and aspects of inhibitor development are being investigated by full-time research staff. This work is presented and discussed in seminars that the trainee will be encouraged to attend. The hemostasis laboratory performs screening and specialized functional and immunologic coagulation tests. The trainee will have a short, basic laboratory training that will include general aspects such as pre-analytical variables, reference ranges, etc, as well as more specific issues such as screening coagulation tests, factor VIII, IX and inhibitor testing.

Multidisciplinary activities/research:  Our multi-disciplinary team includes professionals who have dedicated their career to hemophilia care and are aware that treatment of hemophilia requires the cooperation of different professionals. The Molecular Biology and Genetic Training Program provides an opportunity to learn basic principles and practical methods and techniques for the molecular diagnosis and genetic counseling of hemophilia. This program is directed towards laboratory technicians, biologists or persons with science-related degrees. The trainees will be introduced to molecular principles, both standard and alternative techniques used in the molecular investigations for hemophilia, including analysis and interpretation of the results, and genetic counseling.

To see a sample curriculum of the training that will be provided, please click on the following links:

Comprehensive care: PDF
Dental care: PDF
Laboratory of Hemostasis: PDF
Molecular Biology and Genetics: PDF
Nursing: PDF
Physiotherapy: PDF

Updated July 2014